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it is rapidly cleaved by carboxypeptidases, which suggests a short plasma residence time Pickart et al., 2018
10.1007/s10142-014-0379-y 96 LieberherrD.WagnerU.DubuisP
It has been shown to reduce the activation of the MAPK/ERK and PI3K/Akt pathways, upregulate the cyclin-dependent kinase inhibitor p21, and trigger mitochondrial apoptosis by downregulating the anti-apoptotic proteins Bcl-2/Bcl-xL ( 3.1.4 Polyphenols: precision miRNA targeting for cancer suppression Curcumin emerges as a potent miRNA modulator with specific targeting of oncogenic and tumor suppressor miRNAs
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