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Many experimental studies have shown that female mice are less susceptible to APAP hepatotoxicity than males and that the sex differences are substantial [17,18,35]

This cytokine regulates lymphocyte activity in the immune system, mainly in response to infection, and promotes the differentiation of immature T cells into both pro-inflammatory T cell subsets in the Th1/Th17 pathways, resulting in acceleration of disease progression, and anti-inflammatory regulatory T cells which maintain cellular immunologic memory to protect the host from reinfection by the same pathogen [75]

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