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If your vial is labeled 5mg/mL and your dose is 0.25mg, you need to draw 5 units on a standard insulin syringe
Other routes would require different dosing entirely due to varying bioavailability
The influence of fasting on liver sulfhydryl groups, glutathione peroxidase and [PMID: 15352379] Laboratory literature summary: The influence of fasting on liver sulfhydryl groups, glutathione peroxidase and glutathione-S-transferase activities in the rat
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