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119 As glucagon can bind to GLP-1R, it may also be able to weakly stimulate insulin secretion through the action of this receptor as well as promote apoptotic resistance, proliferation and increased glucose sensing, as all of these effects are associated with GLP-1R activation
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Some patients find that switching from injection to oral semaglutide reduces neurological side effects while maintaining therapeutic benefit, offering a valuable alternative when headaches prove problematic
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