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While it has been in research for over 20 years, it has recently gained a second life thanks to the massive public interest in peptide therapy and the rise of GLP-1 medications.
Patients with early hereditary optic nerve atrophy, cyanocobalmin hypersensitivity, and those who are pregnant
However studies in both humans and dogs have demonstrated oral supplementation of cyanocobalmin will correct B12 deficiencies (3)
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