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Strategies to reduce cumulative exposure include treatment-free remission (TFR) in patients achieving deep molecular responses, as well as experimental intermittent dosing regimens designed to allow partial recovery of spermatogonial stem cells (SSCs)
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However, some studies have reported elevated adiponectin levels in advanced liver disease and HCC, indicating that the effects of adiponectin may vary depending on the stage of liver pathology [219]
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