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In chronic pain and depression, morphological and functional neuroplastic changes were found most pronounced in fronto-limbic regions (Mutso et al., 2012
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Di Cristo F, Calarco A, Digilio FA, Sinicropi MS, Rosano C, Galderisi U, Melone MAB, Saturnino C, Peluso G (2020) The discovery of highly potent THP derivatives as OCTN2 inhibitors: from structure-based virtual screening to in vivo biological activity
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