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In healthy individuals, GLP-1 is released after food consumption, particularly in response to proteins and fats, signaling satiety and stimulating insulin secretion

Wegovys GI side effects (nausea, vomiting, diarrhoea) can lead to fluid loss

If you find yourself in this situation, monitor glucose closely if diabetic, reduce sulfonylurea or insulin doses preemptively, and start retatrutide at 2 mg without escalation until 4 to 6 weeks have passed

When mice on the medications are given cocaine, they experience smaller surges of dopamine than normal mice, but otherwise they maintain adequate amounts of the neurotransmitter