The duration of a B12 shot's effects can vary depending on individual health, frequency of administration, and the body's needs
Gallo S, Comeau K, Vanstone C, Agellon S, Sharma A, Jones G, et al

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The 50-64 age group is the most likely to have used these medications to treat chronic conditions (9%), while 5% of this group had used them for weight loss, and another 5% had used them for both chronic conditions and weight loss