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Co-administration of HIF inhibitors with immune checkpoint blockade (e.g., anti-PD-1/PD-L1), angiogenesis inhibitors (e.g., bevacizumab), or metabolic modulators (e.g., glutaminase inhibitors) may produce synergistic antitumor responses
At the molecular level, receptor activation, cAMP elevation, and enzyme activation occur within this timeframe, initiating lipolysis relatively quickly
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