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This was attributed to the ability of the methoxy group to stabilize the increasing positive charge at the selenium atom during the ratedetermining step of the catalytic cycle, which involves the oxidation of Se(II) to Se(IV), thus improved their catalytic activity to levels comparable with their aliphatic counterparts [56]
The two drugs produce overlapping but non-identical effects through different pathways
The question is never "animal model or computer model." It is "which model for which question at which stage." Every regulatory submission, every go/no-go decision, every safety signal requires a defined Context of Use
Depending on patient needs and treatment objectives, these therapies could be given topically, orally, or via injections
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