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Run-in diet and standardized meals To minimize TMAO production from sources other than the OCC, participants followed a 48-h low-carnitine (and low-ellagitannin) run-in diet before Phase I and II visits (Figure 2), using a list of foods to avoid during the run-in period
J Clin Exp Hepatol 5:190198 Jojima T, Tomotsune T, Iijima T et al (2016) Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes
Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied
Simons, M
