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Since tirzepatide and retatrutide both affect GLP-1-related pathways, similar caution may apply
The proposed mechanism begins with reduced NNMT activity but extends into several interconnected pathways
GLP1R encodes the receptor these compounds target, FTO influences fat-mass and obesity risk, MC4R governs satiety and energy balance, and TCF7L2 ties to glucose control and GLP-1 secretion
Wu Y, Fan Y, Xue B, Luo L, Shen J, Zhang S et al
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