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For confirmed GHD in a 12, 17-year-old, rhGH is typically the standard of care endorsed by the Endocrine Society [7] and the American Association of Clinical Endocrinology [15]
El dato animal de Tomas 1993 Tomas 1993 (Long-R3-IGF-1) administr Long-R3-IGF-1 subcutneo a ratas en restriccin calrica y report: Aumento significativo de ganancia de peso vs ratas controles a dieta similar Retencin de nitrgeno indicando preservacin de masa magra Eficacia mayor que IGF-1 nativo a dosis equimolar (consistente con la potencia in vitro 3) El hallazgo es mecansticamente coherente : ms IGF-1 libre ms seal en IGF-1R ms anabolismo en msculo y otros tejidos receptivos
Its half-life is particularly short, it is easy to eliminate, and it is easily degraded rapidly by dipeptidyl peptidase-4 (DPP-4) in the blood, which is metabolized mainly by the liver and excreted by the kidney (16)
These adverse effects were primarily noted in people with type 2 diabetes who were using the medications
