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Statistical analysis The statistical analyses were based on the intention-to-treat principle using data from the in-trial period and included all randomized patients irrespective of adherence to semaglutide or placebo or changes to background medications

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This means patients who have type 2 diabetes requiring better glycemic control, or patients with obesity (BMI 30 or above, or BMI 27 or above with weight-related comorbidities ) who need weight management assistance

In this Review, we summarize the current clinical evidence for GLP-1 receptor agonists and cancer risk, including thyroid, pancreatic, gastrointestinal, and hormone-dependent malignancies