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The antinociceptive effect was completely blocked by minocycline (a microglial inhibitor), -endorphin antiserum, or naloxone (an opioid receptor antagonist) [24]

Rare cases of intestinal obstruction and acute kidney injury (associated with dehydration) have been reported in post-marketing surveillance

"If you lose less than 5 percent of your total weight within six months of starting the medication, you're most likely a non-responder and these types of medications will not work for you." In addition, severe side effects are possible

The risk of TC associated with liraglutide has been examined in rodent and non-human primate animal model studies