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452 Endothelial cells exhibit enhanced NO production and concurrent suppression of endothelin formation, resulting in vascular smooth muscle relaxation and vasodilation mediated by the endothelium (e.g., GLP-1, exenatide, and liraglutide)
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History has shown that some therapies with promising early research continue to perform well as human evidence grows, while others reveal limitations that werent obvious during the early stages of investigation
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