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It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61
The SAFE Drugs Act was designed to tighten controls around copies of FDA-approved drugs and limit pathways that allow those drugs to circulate outside the FDA approval system
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