nash tirzepatide achieves high resolution in phase 2 trial Eli Lilly's tirzepatide shows promise

Scientists have identified variants in the gene coding for the enzyme PAM (peptidyl-glycine alpha-amidating monooxygenase) that appears to cause GLP-1 resistance

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Other examples of potential functional interactions might include the receptor for long-chain saturated fatty acids, FFA1, which is also expressed in pancreatic beta cells, where its activation leads to GSIS potentiation via G q transducer pathways (Kimura et al., 2020), as well as in hepatocytes (Secor et al., 2021) and enteroendocrine L and K cells, where it contributes to incretin hormone secretion, with FFA1 KO mice exhibiting obesity on a low-fat diet (Lu et al., 2021)

Hoffmeyer, Genve (Orthopdie)