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Out of the current antidiabetic medications, 2.4 mg semaglutide OW is the only one approved for the treatment of MASH by FDA Phase 3 trials with tirzepatide and dual GLP-1/glucagon agonist survodutide are ongoing Many other GLP-1-based emerging medications such as cagrilintide/semaglutide, triple GLP-1/GIP/glucagon agonist retatrutide, small non-peptide GLP-1 agonist orforglipron and many others may also have a great potential to improve MASLD or MASH Based on the excellent review paper by Scott Isaacs, MD, FACP, FACE and colleagues published in Frontline Gastroenterology #mash #mafld #antidiabeticmedication #semaglutide #tirzepatide #survodutide #pioglitazone #insulin #metformin #cvcomplications To view or add a comment, sign in Here's an excellent summary of role and benefits of anti-diabetic treatment options for the clinical management of MASH/MASLD

[1] The clinical trial data for semaglutide at the 2.4mg dose used in Wegovy did not identify menstrual irregularities or intermenstrual bleeding as a direct adverse effect of the medication