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A lower BMR means less heat production overall, which can contribute to cold sensitivity, particularly during the first few months of treatment or after a dosage increase

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In certain specialist settings, metformin may occasionally be considered for conditions such as polycystic ovary syndrome (PCOS) or prediabetes where weight management is clinically important, but this represents individualised care rather than routine practice

Proper handling helps maintain the sterility of the vial and ensures the solution remains uncontaminated