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There is no robust clinical evidence that vitamin B12 pills cause weight loss in people who are not deficient, and neither NICE nor the NHS recommends B12 supplementation as a weight management strategy

[19] The enzymes that use B 12 as a built-in cofactor are methylmalonyl-CoA mutase (PDB 4REQ [43] ) and methionine synthase (PDB 1Q8J)

They may be recommended for people with B12 deficiency or those who have trouble absorbing B12 from food or supplements

Injection technique Subcutaneous injection is straightforward: Clean injection site with alcohol swab Pinch skin to create a fold Insert needle at 45-90 degree angle Inject slowly Remove needle and apply gentle pressure Common injection sites: abdomen (2 inches from navel), thighs, love handles