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The pharmacokinetic barrier has recently been overcome with the synthesis of the orally active, blood-brain barrierpermeable analog N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide (dihexa)
Most therapeutic protocols use 12-24 week cycles based on research protocols and individual goals
However, its important to note that 24 weeks, while substantial for clinical trials, represents a relatively limited timeframe for assessing lifetime exposure safety
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