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A reduction in vascular endothelial cells has been shown to increase the self-renewal capacity of CD133 + brain CSCs in vivo by suppressing the ERBB2 or VEGF signaling pathways

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Studies on -synuclein demonstrate that methionine residues near the N-terminus are more susceptible to copper-mediated oxidation than internal residues, with Met1 substitution decreasing Cu-peptide reduction potential by approximately 80 mV

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