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While canonical ferroptosis regulation centers on cystine uptake and GPX4-mediated GSH utilization, the endogenous metabolic pathways governing ferroptosis sensitivity in liver tumors remain incompletely understood

We observed significant changes in metabolic pathways in response to diet in females, with some overlap in the response to DL and CR feeding, while males showed many fewer changes with no overlapping changes between the DL and CR groups

In diabetic rat models, fasting blood glucose levels are inversely correlated with plasma H 2 S levels and H 2 S synthesis activity