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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

Hypothalamic neuronal preparations characterise the compound's effects on appetite-related circuits in the arcuate nucleus (POMC and AgRP neurons) and the paraventricular nucleus

If the vial label, prescription directions, and pharmacy instructions do not match, stop and ask the pharmacy or prescriber before using it