Procesos validados: Cada etapa, desde el abastecimiento de materias primas hasta el envasado final, se somete a una validacin rigurosa
B12 (cobalamin) is a water-soluble vitamin essential for neurological function, red blood cell formation, and DNA synthesis Joint pain is not listed as a recognised adverse effect in the BNF or licensed B12 product information When joint discomfort occurs after starting B12, it is typically coincidental or related to excipients, injection technique, or pre-existing conditions Severe B12 deficiency itself can cause neuropathic symptoms that may be misinterpreted as joint pain Do not discontinue prescribed B12 treatment without medical guidance, particularly for confirmed deficiency or pernicious anaemia Seek prompt medical advice for severe joint pain, hot swollen joints with fever, or symptoms of allergic reaction Table of Contents Can Vitamin B12 Cause Joint Pain
Editor information Editors and Affiliations Rights and permissions Copyright information 2011 Springer Science+Business Media, LLC About this chapter Cite this chapter Sinigaglia-Coimbra, R., Lopes, A.C., Coimbra, C.G
Based on the impact of PfK13 mutations on hemoglobin uptake and GSH levels in the parasite, one can hypothesise that a decrease in redox-active ferrous heme in artemisinin resistant parasites leads to elevated GSH within the cell, potentially making them more tolerant to artemisinin-induced oxidative stress