Tendon pain may be related to overuse, poor loading mechanics, inflammation, partial tearing, inadequate recovery, metabolic health, medication exposure, or age-related tissue changes
Evidence level: Limited human evidence Sources: PCO-02 safety and pharmacokinetics trial, Intra-articular injection of BPC 157 for multiple types of knee pain How to read this: The registry record has no efficacy result, and the published knee report is retrospective, uncontrolled, and based on telephone follow-up
Severe tears requiring surgery represent a different situation where peptides might support post-surgical healing rather than replacing surgical intervention
Peptides like ipamorelin and CJC-1295 without DAC have narrow activity windows where the delivery profile affects the magnitude of the downstream response