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Diabetes Obes Metab 9:869878 Ahren B, Foley JE, Ferrannini E et al (2010) Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy

Its complex cobalt-containing structure is what makes it biologically active, but that complexity is also its Achilles' heel

Used with lifestyle changes, weekly GLP1/GIP medication resulted in a mean 10% to 15% weight loss (10 to 15 kg) over 68 weeks versus 2% to 3% (3 to 4 kg) with placebo (PC)

Glutathione levels decline roughly 1015% per decade after age 20, which makes IV supplementation increasingly relevant with age