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It requires chronic management
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Importantly, PDS5B addition led to a marked enhancement of the amount of duplex DNA captured by the presynaptic filament with ss-dsDNA complementarity being dispensable for the activity as revealed by testing duplex substrates that harbor no homology or a region homologous to the ssDNA (Fig
The earliest expected NDA filing with the FDA is Q4 2026, which would put a realistic FDA decision in 2027 or later
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