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When adding it to a lyophilised peptide vial, inject slowly down the inner glass wall rather than directly onto the powder, then swirl gently until dissolved and never shake or vortex

Abbreviations CVOTs: Cardiovascular outcome trials DPP-4 inhibitors: Dipeptidyl peptidase-4 inhibitors GLP-1RA: Glucagon-like peptide-1 receptor agonists SGLT-2 inhibitors: Sodium-glucose cotransporter 2 inhibitors MACE: Major cardiovascular events RR: Risk ratio HHF: Hospitalization for heart failure References IDF Diabetes Atlas 2021 10th edition

& Hkanson, R

This adaptation, while energy-conserving, manifests as increased cold sensitivity