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Collectively, all GLP-1 receptor agonists, including native GLP-1, peptides, and small molecule GLP-1 receptor agonists, stabilize the binding pocket of the GLP-1 receptor in a similar fashion, which induces the TM helices 6 kink, a distinctive feature of the active state of the class B1 GPCR
To understand this, you need to know about a peptide called GHK-Cu
However, whether these factors are causally related to CAD has been questioned in MR studies [45, 46], and we found no difference by sex in the risk factors
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