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Other groups including ICI, (later AstraZeneca), Abbott- Takeda and Hoechst AG, (later Aventis) also developed depot formulations of their respective LH-RH agonists, goserelin, leuprolide, and buserelin consisting of microcapsules or implants in poly (lactide-glycolide) or other polymers administered once a month 3
Patients who remain at lower doses (2.55 mg) due to side effect concerns may not achieve optimal therapeutic benefit
The FDA published a December 2024 warning letter to a compounding facility in Texas that sold adulterated products without adequate labeling
Archer SL
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