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Furthermore, on day 42 of the study, cats in all L-carnitine supplemented groups showed a significantly lower respiratory quotient (RQ) compared to their baseline values and the control group throughout the restricted feeding period, indicating their bodies relied more heavily on fat for energy

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Moreover, mitochondria-targeted antioxidant Mito-Tempo alleviates diabetic tubular injury and TECs apoptosis by reducing mitochondrial double-stranded RNA release and inhibiting the activation of the PKR/eIF2 signaling pathway (109), indicating that mitochondria quality control dysfunction is a significant upstreaming point in regulating apoptosis