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Researchers should note that PT-141 produces a transient, dose-dependent increase in blood pressure it must not be used by individuals with cardiovascular disease, uncontrolled hypertension, or high cardiovascular risk, and must not be self-administered or used outside a controlled laboratory environment

Such models are used to evaluate signaling interactions, biomarker expression, and structural organization under controlled laboratory conditions, with emphasis on reproducibility and mechanistic interpretation rather than applied outcomes