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Fessler EB, Chibane FL, Wang Z, Chuang DM

Key points Blood pressure is determined by the interplay of genetic factors including rare variants with large effect sizes that cause monogenic hypertension syndromes and common variants with small effect sizes that contribute to polygenic cases of hypertension and non-genetic factors such as diet and the microbiome

Dominant role of the niche in melanocyte stem-cell fate determination