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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively
Rodent protocols use 50100 higher per-kilogram doses because metabolic rate, receptor density, and clearance kinetics differ across species
McGrath-Morrow and J
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