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Its primary biological function is to protect cellular machinery from oxidative stress by neutralizing reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are natural but destructive byproducts of cellular energy production
To enable self-delivery into mammalian cells, we reconstitute evolved proteases with a native BoNT translocation domain, selectively killing cultured cancer cells while sparing non-cancerous cells
In one animal model, when compared to platelet-derived growth factor, after eight days it was roughly equivalent (2)
Phase I study of dolastatin-10 in refractory or relapsed acute leukemia
