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The estimated mean reduction in HbA1c was -2.01 percentage points, -2.24 percentage points, and -2.30 percentage points with tirzepatide doses of 5 mg, 10 mg, and 15 mg, respectively, compared to -1.86 percentage points with semaglutide
All mice were approved by the Laboratory Animal Welfare Ethics committee at Harbin Institute of Technology (Approval No: IACUC- 2024138) and conducted in accordance with the Guide for Care and Use of Laboratory Animals and the institutional ethical guidelines for animal experiments
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