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Subsequent gene-expression analyses cited in the review identified GHK-Cu as modulating expression of approximately one-third of human genes, with a pattern consistent with reversal of age-related transcriptomic shifts

In the OASIS-1 study, 13% of participants (people with obesity without diabetes) receiving oral semaglutide 50 mg experienced altered skin sensation events compared to 1% with placebo - these events were generally mild to moderate in severity, occurred during dose escalation to the higher doses and resolved without requiring permanent treatment discontinuation [21]

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