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Es una respuesta mdica a una disfuncin real del sistema endocrino
In an osteoarthritis model, a single liraglutide injection decreased synovitis and pain sensitivity, without affecting body weight
Accordingly, excess DPP-4, derived from adipocytes and/or hepatocytes, may act as a local mediator of inflammation and adipose/hepatic tissue insulin resistance, thereby forming one link between obesity and the pathogenesis of T2DM and metabolic disease (Figure 3)
That shift is far from complete
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