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Use bacteriostatic water for reconstitution, not sterile water, because the benzyl alcohol preservative in bacteriostatic water inhibits microbial growth in the vial throughout the usage period

If the patient is suspected to be sensitive to cobalt or other components of cobalamin, an intradermal test dose is recommended.[12][15] Several laboratory tests should be performed prior to treatment with cyanocobalamin, including serum vitamin B12, folate, iron, hematocrit, and reticulocyte count

[8] There are no adequate animal reproduction or controlled human studies evaluating GHK-Cu exposure during pregnancy or lactation