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We included adults with type 2 diabetes who were prescribed a GLP-1 receptor agonist, SGLT2 inhibitor, or both between January 1, 2015, and June 29, 2024
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The acylation on K20 P by Glu-2OEG linker and C18 fatty diacid moiety that enables enhanced binding to plasma albumin and extended the peptide half-life in viv o 25 were not resolved in both structures, indicating a high conformational flexibility, in line with the recently published cryo-EM structure of semaglutide-bound GLP-1R 26 and our molecular dynamics (MD) simulation results (Fig
Related peptides used to investigate these signaling pathways may also be available within the NewBioRx catalog to support laboratory research in cellular signaling and structural biology
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