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Further search for antidepressant agents should take into account anti-inflammatory drugs, for example, cyclooxygenase-2 inhibitors, might exert antidepressant effects by acting on serotonergic deficiency, glutamatergic hyperfunction and antagonizing neurotoxic effects of quinolinic acid

Most side effects are related to dose escalation speed, and skipping steps significantly increases the risk of severe nausea and vomiting

2025 Apr;122(2):e70182

The systems medicine view of semaglutide: from laboratory trials to molecular mechanisms [PMID: 42339860] Laboratory literature summary: The systems medicine view of semaglutide: from laboratory trials to molecular mechanisms