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Preconditioning protocols may further confer protection by raising the threshold for mPTP opening, effectively shifting the safe return point and expanding the intervention window ( 2.4 Extreme inflammation: MAS and CRS In severe cases, uncontrolled mtDAMP release may push SIRS into macrophage activation syndrome or cytokine stormlife-threatening states with explosive IL-1, IL-6, IL-18 and TNF- elevation, plus hemodynamic collapse
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