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Articles including topical CAIs were included, but those that involved systemic CAIs were excluded

29 Clinical trials assessing the efficacy of LOLA showed that it is at least comparable (sometimes superior) to other interventions (such as lactulose or oral antibiotics), in addition to being well-tolerated and associated with improvement in quality of life

This combination is particularly beneficial in research focused on long-term muscle recovery

For the statistics of stress reporter assay data, R (3.3.2) (R Core Team, 2017) and nlme (Pinheiro et al., 2009) (nlme: Linear and Nonlinear Mixed Effects Model) was used to perform a linear mixed effect model for longitudinal data with the following call: lme [value time treatment_dose, random = time | plateID, correlation = corAR1 (form = 1 |plateID)]