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The recent discovery of the small molecule N6F11, which binds the tripartite region of Trim25 and promotes proteasome-degradation of GPX4 in pancreatic cancer cells, while sparing immune cells and the anti-tumoral response of the microenvironment, could represent a major clinical breakthrough for the use of GPX4 inhibitor/degrader [61]
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About the Study The researchers conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, and the study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) prior to data collection
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