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Interestingly, frameshift mutations disrupting the C-terminal DNA binding interface of PDS5B (c.3939dup and c.3954del) have been identified in gastrointestinal cancers 37 , underscoring the possible significance of the PDS5B DNA binding attribute in tumor suppression, and indicating that cancers harboring PDS5B mutations could be targeted with PARP inhibitors 38
A post-treatment analysis from 2024 found that keeping up with exercise after stopping GLP-1 receptor agonists was associated with less weight regain
It is also approved for adolescents aged 12 years and older with obesity and body weight above 60 kg
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