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Free radical damage contributes to aging and disease

In the normal physiological state, Akkermansia muciniphila , with its unique cellular structure and metabolites, is closely bound with intestinal epithelial cells to maintain the integrity of intestinal mucosa, prevent the invasion of harmful substances, and ensure the stability of the intestinal environment (Garcia-Vello et al., 2024)

negatively charged AgNPs target malignant cells, while rare positively charged ones, usually protein-capped, can harm both healthy and cancerous cells indiscriminately

R While Gilbert syndrome itself is considered benign, reduced UGT1A1 activity also impairs glucuronidation of drugs (irinotecan toxicity is dramatically increased in UGT1A1*28 homozygotes) and estrogens