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Under homeostatic physiological conditions, activated microglia and astrocytes can produce ROS and nitric oxide (NO) molecules that play roles in defense mechanisms against microbial pathogens
While necessary, this phase transforms toxins into "reactive intermediate metabolites" that are frequently more toxic and volatile than the original substance, generating massive amounts of free radicals
The renoprotective effect of GLP-1RA can be achieved by reducing urinary protein levels and the glomerular filtration rate (66, 67)
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